Euphobia heterophylla is a local medicinal plant used in ethnomedicine for the treatment of
constipation, bronchitis and asthma. The aqueous decoction and the methanolic extracts were
subjected to anti-inflammatory activity using experimental animal model, in the presence of the positive
control drugs. The inflammation was induced by carraegenean. From the results obtained the aqueous
extract showed significant activity (P < 0.001) comparable to the reference drug used. At the different
dose range used (50, 100 and 150 mg/kg), there was no significant differences in their anti-inflammatory
activity hence they were not dose-dependent. However, the methanolic extract did not show any
appreciable activity (20-24% inhibition) and were also not dose-dependent. The results of the study
showed the justification of the use of the plant in the treatment of inflammatory disease conditions, and
the active chemical constituents when isolated will be added to the present anti-inflammatory agents.